Leptospirosis vaccines

Leptospirosis vaccines

Leptospirosis is a serious infection disease caused by pathogenic strains of the Leptospira spirochetes, which affects not only humans but also animals. It has long been expected to find an effective vaccine to prevent leptospirosis through immunization of high risk humans or animals. Although some leptospirosis vaccines have been obtained, the vaccination is relatively unsuccessful in clinical...

Leptospirosis vaccines: past, present, and future.

It is well known that Leptospira vaccine prevents the disease. However specificity for serovars limits the efficacy of killed whole cell vaccines. Leptospiral antigens that induce cross-protective immunity to the various serovars are sought as new vaccine candidates. In this paper, we have summarized both past and current findings about leptospiral antigens that are conserved among pathogenic l...

Leptospirosis outcomes in pregnancy

Introduction: Leptospirosis is a serious disease of humans, caused by different strains of the ‎bacteria Leptospira. The disease in humans can include pregnant mothers with poor outcomes ‎such as intrauterine fetal death, abortion, and delivery of a newborn with signs of congenital ‎leptospirosis. Moreover, due to overlapping signs and symptoms, leptospirosis is often ‎difficult...

Canine leptospirosis.

Leptospirosis is a common zoonotic disease with a worldwide distribution. Dogs become infected by exposure to contaminated urine from shedding wild animals. The bacteria penetrate mucus membranes, causing endothelial damage and damage to organs, such as the liver and kidneys. The clinical signs and clinicopathologic data are nonspecific and a high index of suspicion is needed by the practitione...

Bovine Leptospirosis